Doximity inked a partnership with Wolters Kluwer Health to embed UpToDate's evidence-based clinical content directly within Doximity Ask, the company’s AI clinical decision support tool.
In the coming weeks, at health systems that use both products, clinicians will see an answer based on UpToDate’s 13,000 clinical topics and best practice guides alongside Doximity Ask’s response, without leaving the Ask workflow.
Doximity is a digital platform for U.S. medical professionals that offers workflow tools such as a telehealth solution, a clinician-to-patient dialer tool and digital faxing capabilities.
The company aims to become a leading AI platform for doctors with plans to scale its clinical AI suite, including its ambient notetaking tool Scribe and clinical AI assistant and medical search engine Ask. A year ago, Doximity acquired clinical AI company Pathway and then integrated Pathway's datasets and its AI into its free Doximity GPT product to offer DoxGPT (now Ask).
As Doximity ramps up its investment in clinical AI tools, the partnership with Wolters Kluwer positions Ask as the front door to clinical knowledge. Wolters Kluwer's UpToDate is a widely used clinical evidence solution that's been on the market for 30 years.
The UpToDate integration gives Doximity another recognizable source of clinical authority to point to alongside its own 12,000-physician PeerCheck program.
As AI models improve, health tech companies are increasingly looking to differentiate their clinical AI tools through trust and safety, not just AI capabilities.
"Every frontier model has read all the same journals. UpToDate stands alone as a gold standard reference from experienced physicians about what happens when there isn't an RCT (randomized controlled trial), a trial that actually answers the questions. We think this real-world layer of what to do in those corner cases is really important to be able to answer all the questions that doctors have, and now we got it one tap away inside of Doximity,” Jeff Tangney, Doximity CEO, told Fierce Healthcare in an interview.
Nearly one in four medical questions can’t be answered by available research. UpToDate provides medical professionals with peer-reviewed medical insights drawing on 7,600 expert clinicians, editors and peer reviewers who regularly review clinical, drug and patient content.
"The number of cases for which clinical research has no direct answer would surprise you,” said Nicholas Perkins, DO, chief clinical analytics officer at Prisma Health, in a statement. “Clinicians rely on trusted resources like UpToDate to support clinical decision-making when evidence is scarce. The ability to access it right within Doximity Ask has the potential to save doctors time so they can focus on helping patients."
Doximity Ask currently focuses on providing clinicians with information to help make clinical decisions. A logical next step for clinical AI tools would be moving from answering questions to taking action based on those decisions, such as helping physicians prescribe medications or draft referrals. Tangney declined to offer details on Doximity’s future roadmap or potential expansion into other AI-driven workflows.
Competition in the clinical AI market is intensifying with new startups going head-to-head with legacy players like Wolters Kluwer's UpToDate. A year ago, Wolters Kluwer jumped into the AI market, launching UpToDate Expert AI, a gen-AI-powered version of its CDS solution. The company positioned the launch as the next evolution of UpToDate, which has more than 3 million clinician users working at thousands of hospitals. The company aims to meet clinicians' need for the speed and power of gen AI with reliable medical knowledge, executives said.
The company has also inked partnerships with electronic health record giant Epic, healthcare AI company Abridge and now Doximity to integrate UpToDate into their AI-powered CDS tools, embedding the clinical resource directly into medical workflows. Suki and Wolters Kluwer also teamed up to launch "Ask," a clinical decision support tool powered by the UpToDate Expert AI API.
Doximity’s membership includes more than 85% of all U.S. doctors, and its clinical AI tools, including Ask, has been deployed across more than 165 health systems, including 10 of the nation's top 20 hospitals, according to the company.
“Trust in clinical AI starts with the intelligence behind the answer. UpToDate combines the latest evidence with expert judgment, peer review, and a rigorous editorial process designed to keep pace with evolving medicine,” Yaw Fellin, senior vice president and general manager, clinical decision support and provider solutions at Wolters Kluwer Health, said in a statement. “Bringing that clinical intelligence into Doximity Ask gives clinicians access to trusted, cited answers within a workflow they already use at the point of care.”
A benchmark study from ARISE, a clinical AI research team of Stanford University School of Medicine and Harvard Medical School physicians, aimed to measure the frequency and severity of patient harm caused by large language model (LLM) recommendations in clinical settings. That study, which evaluated how AI models perform when researchers prompted them with simulated patient cases, found that clinically specialized AI tools, including Doximity Ask, significantly outperform general-purpose models.
Tangney said the industry needs more rigorous, independent physician-led research like this.
Doximity executives aim to position Doximity at the intersection of clinical AI safety and physician trust and contend this will be a competitive advantage as hospitals and health systems increasingly adopt enterprise AI platforms.
“UpToDate is the clinical decision support reference that all these systems use, and their doctors trust it. They have genuine trust issues; trust is the number one issue with AI answers. So, by working with them, I think we've helped address the trust issue of 'Am I referring to what my colleagues, what experts in my field have to say about something?' We're filling in all those gaps for those questions that aren't answered by published journals and trials,” Tangney said.
Doximity is seeing strong uptake of its AI tools among physicians. Quarterly active workflow prescribers grew more than 30% year-on-year to "record highs" with nearly half of those prescribers using the company's AI tools in Q1, executives said during the company’s fiscal first-quarter earnings call in August. AI prompt volume was up more than 25% quarter-on-quarter, while Doximity's AI Scribe notetaking users grew 10x from July 2025 to July 2026.
Doximity executives assert they are building a comprehensive digital AI assistant for doctors, including telehealth tools, that gives the company a distinct competitive advantage in a competitive market.
“Those three things together, Dialer, Scribe and Ask, we believe are the physician's personal assistant, or the Microsoft Office of being a physician. We’re one of the top three players in each of those three areas, and I think we can bring those together to offer a seamless experience for the doctors,” Tangney told Fierce Healthcare this week.